GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12522034 | 1 | rs4869660 | chr5:36424281 | UGT3A2 | chr5:36035124-36066984:- | -0.2 | -3.78 | 0.000176 | Hypertension |
| THCA | cis | rs9371538 | 1 | rs4870040 | chr6:151872090 | C6orf97 | chr6:151815175-151942327:+ | 0.3 | 4.29 | 2.13E-5 | Bone mineral density (spine) |
| THCA | cis | rs9371538 | 1 | rs4870041 | chr6:151872324 | C6orf97 | chr6:151815175-151942327:+ | 0.3 | 4.33 | 1.84E-5 | Bone mineral density (spine) |
| THCA | cis | rs1056667 | 1 | rs4871 | chr6:26545632 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.31 | 1.98E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4871 | chr6:26545632 | HCG11 | chr6:26521934-26527610:+ | -0.22 | -4.33 | 1.85E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4871 | chr6:26545632 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.04 | 6.18E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs4871 | chr6:26545632 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.91 | 0.000107 | Educational attainment |
| THCA | cis | rs4463516 | 1 | rs4879620 | chr9:32863942 | TAF1L | chr9:32629452-32635667:- | 0.1 | 3.39 | 0.000748 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs4879901 | 1 | rs4879901 | chr9:35518997 | FAM166B | chr9:35561945-35563896:- | 0.27 | 5.74 | 1.69E-8 | Schizophrenia |
| THCA | cis | rs4879901 | 1 | rs4879902 | chr9:35519359 | FAM166B | chr9:35561945-35563896:- | -0.28 | -5.75 | 1.56E-8 | Schizophrenia |
| THCA | cis | rs670523 | 1 | rs488079 | chr1:155890581 | FDPS | chr1:155278539-155290457:+ | -0.21 | -4.32 | 1.89E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs670523 | 1 | rs488079 | chr1:155890581 | RIT1 | chr1:155867601-155881177:- | 0.17 | 3.86 | 0.00013 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs4883201 | 1 | rs4883201 | chr12:9082581 | KLRG1 | chr12:9142221-9163338:+ | -0.21 | -3.94 | 9.3E-5 | Cholesterol, total |
| THCA | cis | rs4883201 | 1 | rs4883201 | chr12:9082581 | LOC144571 | chr12:9217773-9220651:+ | -0.21 | -4.69 | 3.56E-6 | Cholesterol, total |
| THCA | cis | rs4883201 | 1 | rs4883201 | chr12:9082581 | M6PR | chr12:9092965-9102252:- | -0.57 | -10.29 | 1.42E-22 | Cholesterol, total |